Myeloid cell 7T ultra-high field magnetic resonance imaging in pigs as a translational platform for cardiac immunotherapy (C03)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

This project aims to establish imaging of myeloid cell infiltration in the myocardium of pigs on a 7 Tesla (7T) magnetic resonace tomography (MRI) platform. Myeloid cells will be labelled by perfluorocarbon emulsions containing 19F-atoms. Measurement techniques will be based on a 7T whole-body clinical MRI system that allows for both 1H and 19F imaging. As a paradigm for future immunotherapy applications, we will image myeloid cells to determine the intensity, dynamics, and beneficial, but not yet fully understood, effects of colchicine after MI.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Major Instrumentation: RF-coil interface
• Instrumentation Group: 3231 MR-Tomographie-Systeme
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Wolfgang Rudolf Bauer; Professor Dr. Ulrich Hofmann; Professorin Dr. Laura Maria Schreiber