Role of lymphocytes for the progression of a genetically determined cardiomyopathy (A05)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

Building on our own data showing that the development of the cardiac phenotype in a mouse model of Duchenne’s cardiomyopathy relies on lymphocytes, this project aims to understand how lymphocytes (T- and B-cells) are activated and influence the development and progression of genetic cardiomyopathy. We hypothesize that the mechanism identified here may also play a role in other non-ischemic cardiomyo- pathies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professor Dr. Ulrich Hofmann