Elucidating the role of monocyte – Treg interactions as key drivers of cardiovascular remodelling after myocardial infarction (A01)

• Subject Area: Cardiology, Angiology ; Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

This project addresses the functional roles of monocytes and regulatory T cells (Treg) during cardiac remodelling after myocardial infarction (MI). Newly developed mouse models we will be used to resolve the temporal dynamic of monocyte subset recruitment and their integration into the cardiac macrophage network during healing. Furthermore, we have identified specific Treg cell subsets and will elucidate their unique roles during cardiac remodelling. We further hypothesise that type IL1-family cytokines and prototypical anti-inflammatory cytokine-dependent interactions are key elements of monocyte – Treg cell communication.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Wolfgang Kastenmüller; Professorin Dr. Alma Zernecke-Madsen