Project Details
Projekt
Crosstalk between T cells and B cells in the differentiation of pathogenic plasma cells in pemphigoid diseases (A02)
Subject Area
Dermatology
Immunology
Immunology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335
The bidirectional crosstalk between B and T cells is crucial to for the evolution of pathogenic autoantibodies. Evidence suggests that IFN-γ and retinoic acid (RA) play a significant role as regulators of this interaction. A02 will investigate the molecular mechanisms of the interaction between B and T cells in the evolution of pathogenic autoantibodies using pemphigoid diseases as prototypical example. Herein, A02 will first focus on the role of IFN-γ and RA in this interaction. The final aim of A02 is to develop new strategies treating autoimmune diseases by targeting the evolution of pathogenic autoantibodies.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1526:
Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
Applicant Institution
Universität zu Lübeck
Project Heads
Professor Dr. Guido Heine; Professor Dr. Rudolf Manz
