Detailseite
Asymmetric protein sorting via localizd translation - The role of ZBP protein in directing mRNA localization and translation
Antragsteller
Professor Dr. Stefan Hüttelmaier
Fachliche Zuordnung
Zellbiologie
Förderung
Förderung von 2007 bis 2015
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 33442413
Zusammenfassung der Projektergebnisse
Keine Zusammenfassung vorhanden
Projektbezogene Publikationen (Auswahl)
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(2009). Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. Rna 15, 104-115
Weidensdorfer, D., Stohr, N., Baude, A., Lederer, M., Kohn, M., Schierhorn, A., Buchmeier, S., Wahle, E., and Huttelmaier, S.
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(2012). IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes & development 26, 176-189
Stohr, N., Kohn, M., Lederer, M., Glass, M., Reinke, C., Singer, R.H., and Huttelmaier, S.
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(2012). IGF2BP1: a post-transcriptional "driver" of tumor cell migration. Cell adhesion & migration 6, 312-318
Stohr, N., and Huttelmaier, S.
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(2014). The role of the oncofetal IGF2 mRNA- binding protein 3 (IGF2BP3) in cancer. Seminars in cancer biology 29C, 3-12
Lederer, M., Bley, N., Schleifer, C., and Huttelmaier, S.
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(2013). IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic acids research 41, 6618-6636
Zirkel, A., Lederer, M., Stohr, N., Pazaitis, N., and Huttelmaier, S.
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(2013). Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cellular and molecular life sciences: CMLS 70, 2657-2675
Bell, J.L., Wachter, K., Muhleck, B., Pazaitis, N., Kohn, M., Lederer, M., and Huttelmaier, S.
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(2013). Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. Biological chemistry 394, 1077-1090
Wachter, K., Kohn, M., Stohr, N., and Huttelmaier, S.
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(2014). Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology 59, 1900-1911
Gutschner, T., Hammerle, M., Pazaitis, N., Bley, N., Fiskin, E., Uckelmann, H., Heim, A., Grobeta, M., Hofmann, N., Geffers, R., Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S