Shaping neuronal engram ensembles through excitation-transcription coupling (A02)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

In this project, we will test the hypothesis that protein transport from synapse to nucleus stabilises CREB transcriptional complexes and may therefore be involved in both memory allocation and memory consolidation following learning. We further propose to harness excitation-transcription coupling via CREB as a neural resource to enhance memory formation. To this end, we will investigate how one can employ the signalling principles of the synapto-nuclear protein messenger Jacob to optimise neuronal engram ensemble formation with particular emphasis on healthy ageing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Anna Karpova, Ph.D.; Dr. Michael R. Kreutz