Mechanisms of globotriaosylceramide-induced dorsal root ganglion pathology and pain in Fabry disease (human-rodent tandem) (A10)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology ; Anaesthesiology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 255156212

Fabry disease (FD) is a genetic disorder, which leads to triggerable acral pain starting in early childhood. The neural circuits and mechanisms underlying pain in FD are incompletely understood. Project A10 will focus on the neuro-cutaneous unit covering the terminal nociceptor, the dorsal root ganglion (DRG), and the first peripheral-to-central synapse, including investigation of neurovascular coupling. Within this pathophysiological framework, the project will investigate potentially druggable targets using novel methods of human and murine DRG imaging in combination with multilevel molecular and electrophysiological analysis employing innervated and fully human cellular in vitro test systems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganisation
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Mirko Pham; Professorin Dr. Claudia Sommer; Professorin Dr. Nurcan Üçeyler