Project Details
Projekt
From primary target inhibition to collapse of the cell envelope biosynthetic network (A10)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
from 2019 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 398967434
Targeting the peptidoglycan precursor lipid II can induce multifactorial cellular effects that go beyond sequestration of the cell wall building block. Teixobactin and related antibiotics target multiple undecaprenyl-coupled lipid intermediates, induce strong lysis and form supramolecular structures upon target interaction. They also have a limited potential for resistance development. We will dissect the cellular signatures induced by teixobactin and teixobactin-like antibiotics and compare these to other cell wall targeting antibiotics. The aim is to unravel on the cellular and molecular level differential mechanisms that converge onto the collapse of highly interlinked cell wall biosynthetic networks.
DFG Programme
CRC/Transregios
Applicant Institution
Eberhard Karls Universität Tübingen
Project Head
Professorin Dr. Tanja Schneider
