Role of autoinducer 2 signalling in shaping spatio-temporal dynamics and host-microbe interactions of the gut microbiota
Microbial Ecology and Applied Microbiology
Final Report Abstract
Bacteria communicate and coordinate their behavior by producing and sensing extracellular small molecules called autoinducers. The astounding structural diversity of these molecules allows bacteria to synchronize their behavior on both intra- and interspecies levels. Autoinducer 2 (AI-2) is produced and detected by a variety of bacteria, thus principally allowing interspecies communication. Although AI-2 is a major autoinducer molecule present in the mammalian gut, its role in bacteria-bacteria and bacteria-host interactions remains elusive. Here, we show that chemotaxis and AI-2 signalling promote gut colonization by Escherichia coli, which is in turn connected to the ability of the bacteria to benefit from utilization of fructoselysine. We further show that the genomic diversity of E. coli strains in respect to AI-2 signaling allows ecological niche segregation and stable co-existence of different E. coli strains in the mammalian gut.
Publications
- Import of aspartate and malate by DcuABC drives H2/fumarate respiration to promote initial Salmonella gut-lumen colonization in mice. Cell Host & Microbe. 27 (6)
BD Nguyen et al.
(See online at https://doi.org/10.1016/j.chom.2020.04.013) - Multiple functions of flagellar motility and chemotaxis in bacterial physiology. FEMS Microbiology Reviews. 45 (6)
Colin, R., Bin, N., Laganenka, L., Sourjik, V.
(See online at https://doi.org/10.1093/femsre/fuab038) - Silicon Nitride, a bioceramic for bione tissue engineering: a reinforces cryogel system with antibiofilm and osteogenic effects. Front in Bioengineering and Biotechnology. 9
Lee, S., Laganenka, L., Du, X., Hardt, W.-D., Ferguson, J.
(See online at https://doi.org/10.3389/fbioe.2021.794586)
