Die Rolle des Autoinducer-2 bei der Gestaltung der räumlich-zeitlichen Dynamik und der Wirt-Mikroben-Interaktionen der Darmmikrobiota
Mikrobielle Ökologie und Angewandte Mikrobiologie
Zusammenfassung der Projektergebnisse
Bacteria communicate and coordinate their behavior by producing and sensing extracellular small molecules called autoinducers. The astounding structural diversity of these molecules allows bacteria to synchronize their behavior on both intra- and interspecies levels. Autoinducer 2 (AI-2) is produced and detected by a variety of bacteria, thus principally allowing interspecies communication. Although AI-2 is a major autoinducer molecule present in the mammalian gut, its role in bacteria-bacteria and bacteria-host interactions remains elusive. Here, we show that chemotaxis and AI-2 signalling promote gut colonization by Escherichia coli, which is in turn connected to the ability of the bacteria to benefit from utilization of fructoselysine. We further show that the genomic diversity of E. coli strains in respect to AI-2 signaling allows ecological niche segregation and stable co-existence of different E. coli strains in the mammalian gut.
Projektbezogene Publikationen (Auswahl)
- Import of aspartate and malate by DcuABC drives H2/fumarate respiration to promote initial Salmonella gut-lumen colonization in mice. Cell Host & Microbe. 27 (6)
BD Nguyen et al.
(Siehe online unter https://doi.org/10.1016/j.chom.2020.04.013) - Multiple functions of flagellar motility and chemotaxis in bacterial physiology. FEMS Microbiology Reviews. 45 (6)
Colin, R., Bin, N., Laganenka, L., Sourjik, V.
(Siehe online unter https://doi.org/10.1093/femsre/fuab038) - Silicon Nitride, a bioceramic for bione tissue engineering: a reinforces cryogel system with antibiofilm and osteogenic effects. Front in Bioengineering and Biotechnology. 9
Lee, S., Laganenka, L., Du, X., Hardt, W.-D., Ferguson, J.
(Siehe online unter https://doi.org/10.3389/fbioe.2021.794586)
