Project Details
Projekt
Functions of RNA in double-strand break repair and DNA end protection (17)
Subject Area
General Genetics and Functional Genome Biology
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 393547839
DNA double-strand breaks must be repaired accurately to prevent chromosome loss or oncogenic transloca-tions. When the ends of linear chromosomes, the telomeres, become critically short, they are treated in a similar manner to a double-strand break. Recently, it has been shown that RNA plays an important, but still undefined role, in double-strand break repair. In this project, we will combine in vitro biochemical approaches with in vivo telomere attrition models to gain mechanistic insights and identify novel components involved in RNA-mediated double-strand break repair and telomere maintenance. In the light of emerging RNA thera-pies, these studies may have important consequences for potential treatments of disease and aging.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1361:
Regulation of DNA Repair and Genome Stability
Applicant Institution
Johannes Gutenberg-Universität Mainz
