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Renoprotection by understanding functional and structural G-protein-coupled receptor activation (A03)

Subject Area Structural Biology
Nephrology
Term from 2019 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635
 
Autoantibodies (immunoglobulins - IgGs) induce several renal pathologies by targeting the G-protein-coupled receptors (GPCRs), Angiotensin II type 1 and Endothelin-1 type A. We aim to identify and characterize determinants and signaling pathways that are specific for pathogenic IgG binding and receptor-activation as compared to endogenous peptide receptor-agonists. By a combination of G-protein signaling assays in yeast or mammalian cells with biophysical in vitro assays, protein X-ray crystallography and cryo-electron microscopy, we will elucidate molecular insights into autoimmune GPCR activation, which finally will support a rational design of new specific renoprotective drugs.
DFG Programme Collaborative Research Centres
Applicant Institution shared FU Berlin and HU Berlin through:
Charité - Universitätsmedizin Berlin
 
 

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