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Projekt Druckansicht

Die Rolle von hepatischen Sternzellen und extrazellulärer Matrix während akuter Leberschädigung.

Fachliche Zuordnung Gastroenterologie
Zellbiologie
Förderung Förderung von 2018 bis 2021
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 417747618
 
Erstellungsjahr 2021

Zusammenfassung der Projektergebnisse

In this project we investigated the myriad functions of hepatic stellate cells in the liver, focusing on acute liver injury and liver cancer. Overall, our studies show that HSC have context-specific functions and that they not only exert disease-promoting but also protective roles: Our findings establish protective functions of HSC in CCl4-, acetaminophen-driven acute liver injury and partial hepatectomy, mediated by the promotion of hepatocyte proliferation as well as the modulation of hepatocyte injury. On the other hand, HSC-derived cancer-associated fibroblasts have dual functions. HSC-CAF derived type 1 collagen restricts tumor growth while HSC-CAF derived hyaluronic acid (HA) and hepatocyte growth factor (HGF) promote tumor growth. Going forward the findings from this project may help to develop new therapeutic approaches to target the tumor promoting arm of CAF while leaving the liver protective/ tumor restrictive arm intact.

Projektbezogene Publikationen (Auswahl)

 
 

Zusatzinformationen

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