Role of platelets in tissue remodelling and functional recovery after experimental cerebral ischaemia (B04+)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971

In B04, we will assess whether platelets play a pathophysiological role during post-stroke recovery and late-stage tissue remodelling. The main focus will be on platelet-mediated thrombo-inflammation as well as potential extravascular effects of platelets, e.g. induction of apoptosis. Translationally meaningful mouse models, novel pharmacological inhibitors, and advanced imaging techniques will be used to investigate our research questions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 240: Platelets – Molecular, cellular and systemic functions in health and disease
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Christoph Kleinschnitz; Professor Dr. Harald Langer