Regulation of the platelet lipidome and its implications in thrombo-inflammation (A08+)

• Subject Area: Hematology, Oncology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971

This project will focus on regulation of the platelet lipidome. We will characterise the molecular mechanisms governing platelet lipid metabolism and its functional consequences on thrombo-inflammation, decipher the dynamic changes in the platelet lipidome under pathophysiological conditions, and its relevance for atheroprogression and organ ischaemia. We will combine transgenic hyperlipidaemic mouse models, high-resolution platelet imaging, and lipidomics approaches to disclose the key players governing platelet lipid metabolism. Besides, novel therapeutic targets will be identified and validated in experimental studies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 240: Platelets – Molecular, cellular and systemic functions in health and disease
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Madhumita Chatterjee, Ph.D.; Professor Dr. Michael Lämmerhofer; Professor Dr. Tilman Schäffer