Project Details
Projekt
Mechanosensitive cGMP signalling in platelets (A05)
Subject Area
Cell Biology
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971
The cyclic nucleotide cGMP is an important signalling molecule of our cardiovascular system and increasingly targeted by clinically used drugs. We have discovered a mechanosensitive cGMP pathway (mechano-cGMP) in mouse and human platelets that is organised by a membrane-associated integrin-cGMP signalosome. In this project, we will study the molecular architecture and mode of action of mechano-cGMP as well as its functional and therapeutic relevance in mouse and human. We hypothesise that the novel link between integrin and cGMP signalling provides a flow/shear-sensitive break mechanism to prevent platelet overactivity in platelet-related disorders.
DFG Programme
CRC/Transregios
Applicant Institution
Julius-Maximilians-Universität Würzburg
Project Heads
Professor Dr. Robert Feil; Dr. Susanne Feil
