Strukturelle und funktionelle Effekte von umschriebenen Läsionektomien im Temporallappen
Zusammenfassung der Projektergebnisse
Epilepsy affects nearly 1% of the world´s population, leading to substantial morbidity and mortality. Hippocampal sclerosis (HS) is the histological hallmark of temporal lobe epilepsy (TLE), the most common drug-refractory syndrome. Nevertheless, in approximately 25% of all TLE patients, seizures originate from neocortical lesions. Moreover, the ipsilateral hippocampus is considered structurally and functionally intact in such patients, allowing for circumscribed lesionectomy without hippocampectomy. Consequently, our purpose was to comprehensively evaluate brain morphology and network topology in neocortical TLE, relative to HS and healthy controls. Based on evidence of widespread structural abnormalities in mesiotemporal TLE, we hypothesize that neocortical TLE equally causes structural alterations distant to the seizure focus, including the hippocampus.
Projektbezogene Publikationen (Auswahl)
- Functional Networks in Epilepsy Presurgical Evaluation. Neurosurg. Clinics of North America 4/2020
Foit, NA, Bernasconi, A. & Bernasconi, N.
(Siehe online unter https://doi.org/10.1016/j.nec.2020.03.004) - “Contributions of Imaging to Neuromodulatory Treatment of Drug-Refractory Epilepsy” Brain Scieces 2020 10/2;10(10):700
Foit NA, Bernasconi A, Bernasconi N
(Siehe online unter https://doi.org/10.3390/brainsci10100700) - “Effects of hippocampus-sparing resections in the temporal lobe: Hippocampal atrophy is associated with a decline in memory performance”; Epilepsia 2020 Apr;61(4):725-734
Wagner K et al. and Foit NA
(Siehe online unter https://doi.org/10.1111/epi.16473) - „Accuracy and practical aspects of semi- and fully automatic segmentation methods for resected brain areas”; Neuroradiology. 2020 Dec; 62(12):1637-1648
Gau K, Schmidt CSM, et.al. and Foit NA
(Siehe online unter https://doi.org/10.1007/s00234-020-02481-1) - An MRI-Based Machine Learning Prediction Framework to Lateralize Hippocampal Sclerosis in Patients with Temporal Lobe Epilepsy”; Neurology. 2021 Sep 2:10.1212
Foit NA and Caldairou BC et al.
(Siehe online unter https://doi.org/10.1212/wnl.0000000000012699) - “A whole-brain myeloarchitectonic atlas: Mapping Vogt-Vogt histological data to the 3D cortical surface”
Foit NA, Yung S et.al Hong SJ
(Siehe online unter https://doi.org/10.1101/2022.01.17.476369)
