Project Details
Projekt
Interplay between calcium signaling and oxidative stress in pathogenic immune cells during CKD and associated CVD (M04 [C09])
Subject Area
Cardiology, Angiology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
Inflammation is a major factor determining progression of CKD and the development of cardiovascular complications. This project aims to specifically unravel the interplay between Ca2+ signaling and oxidative stress as central regulators of inflammation during CKD and its associated cardiovascular complications. It will provide detailed mechanistic insights into altered ion channel profiles in CKD and their interplay with local generation of reactive oxygen species, leading to altered pro-inflammatory cytokine release and the modulation of immune and cardiac cells contributing to cardiorenal pathology.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Heads
Professor Dr. Christoph Maack, until 12/2021; Professorin Barbara Anne Niemeyer, Ph.D., since 1/2022; Professorin Leticia Prates Roma, Ph.D.; Professor Thimoteus Speer, Ph.D., since 1/2022
