Interplay between calcium signaling and oxidative stress in pathogenic immune cells during CKD and associated CVD (M04 [C09])

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

Inflammation is a major factor determining progression of CKD and the development of cardiovascular complications. This project aims to specifically unravel the interplay between Ca2+ signaling and oxidative stress as central regulators of inflammation during CKD and its associated cardiovascular complications. It will provide detailed mechanistic insights into altered ion channel profiles in CKD and their interplay with local generation of reactive oxygen species, leading to altered pro-inflammatory cytokine release and the modulation of immune and cardiac cells contributing to cardiorenal pathology.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Christoph Maack, until 12/2021; Professorin Dr. Barbara Anne Niemeyer, Ph.D., since 1/2022; Professorin Dr. Leticia Prates Roma, Ph.D.; Professor Dr. Thimoteus Speer, Ph.D., since 1/2022