PDGFR-Signalisierung bei CVD in CKD (M01)

• Subject Area: Pathology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

We have recently defined the role of PDGFR in CKD, particularly in mediating fibrosis and angiogenesis. Our pilot data showed an increased expression of PDGFR-α in uremic cardiomyopathy and vasculopathy. This project aims to analyze our hypothesis, that PDGFR-α signaling mediates CKD-associated CVD, which will stimulate further translational development of PDGFR-based diagnostic and therapeutic approaches also the pathological kidney-heart crosstalk in CKD patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Peter Boor, Ph.D.; Professor Dr. Jürgen Floege, until 12/2021