The role of post-translational modifications of sortilin receptors in CKD (C02)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

Recently, we identified the intracellular sorting receptor sortilin as a calcification promotor and the soluble, circulating form as a cardiovascular risk factor in the general population. We demonstrated that circulating sortilin is post-translationally modified in patients with impaired kidney function. The overall hypothesis is that circulating sortilin undergoes directed post-translational modification and thereby functionally promotes cardiovascular calcification. This project aims to characterize in detail the mechanisms and importance of post-translationally modified sortilin in CKD. This may lead to the development of potential therapies targeting post-translational protein modifications and thereby provide opportunities to treat CVD in CKD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Claudia Göttsch, Ph.D.