Deciphering the role of HLA-DO in immune responses after allogeneic stem cell transplantation (A01)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

For a selective GvL effect without GvHD promising targets of CD4+ T cells are DM-sensitive antigens, whose immunogenicity has already been confirmed in a mouse model in the first period. To analyze clinical relevance, the frequency of allogeneic T cells directed against DM-sensitive antigens will be correlated with the GvL effect and GvHD after HSCT. The influence of 5-azacytidine on the regulation of HLA-DO has already been observed in vitro and will now be further investigated in primary leukemia cells. Finally, T cells directed against DM-sensitive antigens in HLA-DP mismatched HSCT will be isolated, sequenced and TCR transgenic T cells will be explored for potential clinical application.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Privatdozentin Dr. Anita Kremer; Dr. Hannah Reimann, since 1/2022