Protein modifications and interactions of the FOXO/DAF-16 and mTORC mediated stress response (P05)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

We focused on the identification of protein modifications and interactions of key components in insulin/IGF and target-of-rapamycin (mTORC) signaling. The serum-and-glucocorticoid-inducible kinase SGK-1 couples both pathways via its dynamic localization and extensive interactions and modifications of its key components. Here, we propose genetic and protein-biochemical methods in C. elegans and cell culture models to understand how stress and nutrition modulate the feedback regulation of SGK-1 via the FOXO transcription factor DAF-16 and the mTORC2 interactor Rictor.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Ralf Baumeister