EGFR-targeted polyglycerol-shelled multifunctional micellar drug conjugates for precision cancer chemotherapy

Applicant Professor Dr. Rainer Haag

Subject Area Biological and Biomimetic Chemistry
Biomaterials
Polymer Materials

Term from 2018 to 2021

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 392192146

Final Report Year 2022

Final Report Abstract

No abstract available

J. Control. Release, 2019, 300, 13-21. Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs
N. Rades, K. Achazi, M. Qiu, C. Deng, R. Haag, Z. Zhong, K. Licha
(See online at https://doi.org/10.1016/j.jconrel.2019.01.035)
J. Control Release, 2020, 329, 676-695. Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation
W. Gu, F. Meng, R. Haag, Z. Zhong
(See online at https://doi.org/10.1016/j.jconrel.2020.10.003)
Adv. Mater. 2021, 33, 2007787. Daratumumab Immunopolymersome-Enabled Safe and CD38-Targeted Chemotherapy and Depletion of Multiple Myeloma
N. Yu, Y. Zhang, J. Li, W. Gu, S. Yue, B. Li, F. Meng, H. Sun, R. Haag, J. Yuan, Z. Zhong
(See online at https://doi.org/10.1002/adma.202007787)
Biomacromolecules 2021, 22, 6, 2625–2640. A toolbox of biodegradable dendritic (poly glycerol sulfate)-SS-poly(ester) micelles for cancer treatment: stability, drug release, and tumor targeting
D. Braatz, M. Dimde, G. Ma, Y. Zhong, M. Tully, C. Grötzinger, Y. Zhang, A. Mavroskoufis, M. Schirner, Z. Zhong, M. Ballauff, R. Haag
(See online at https://doi.org/10.1021/acs.biomac.1c00333)
J. Control Release, 2021, 340, 331-341. An intelligent cell-selective polymersome-DM1 nanotoxin toward triple negative breast cancer
Y. Zhang, S. Yue, R. Haag, H. Sun, Z. Zhong
(See online at https://doi.org/10.1016/j.jconrel.2021.11.014)