The role of human microbiota for the development of fungal infectious diseases – Candida albicans as a case study (B05)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210879364

The main hypothesis is that the observed high rate of C. albicans infections in patients undergoing chemotherapeutic or antibiotic treatment is highly interconnected with drug-induced imbalances of the intestinal ecosystem. B5 will determine the composition and functionality of bacteria and viruses from human and mouse gut. B5 will examine how microbes influence the colonisation of C. albicans. By high throughput sequencing, metagenome and metatranscriptome data from different time points before and after colonization/infection will be generated. Also, regulatory genes (e.g. ncRNAs) will be identified.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professorin Dr. Manja Marz; Professor Gianni Panagiotou, Ph.D.