HIF-MYC/MAX pathway in neural-crest derived catecholamine producing tumours: Identification of a metabolic fingerprint related to tumour aggressiveness (B12)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Organic Molecular Chemistry - Synthesis and Characterisation ; Pneumology, Thoracic Surgery
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

Establish functional links between hypoxia pathways, tumour differentiation and aggressiveness in different NCCP tumours.(II) Investigate the mechanisms involving the MYC/MAX complex, by which HIF2a and HIF1a differentially affect NCCP tumour aggressiveness.(III) Identify and establish clinical predictors and metabolic fingerprints related to NCCP tumour aggressiveness as diagnostic and prognostic tools for the prediction of disease progression and malignancy.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• International Connection: Luxembourg
• Applicant Institution: Technische Universität Dresden
• Project Heads: Dr. Nicole Bechmann, since 7/2021; Professor Graeme Eisenhofer, Ph.D.; Dr. Barbara Klink, until 6/2021; Professor Jacques W.M. Lenders, Ph.D., until 6/2021