Project Details
Projekt
GRK 1044: Developmental and Disease-induced Modifications of the Nervous System
Subject Area
Medicine
Term
from 2004 to 2013
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 375129
Neuropathological modifications reactivate genetically determined programmes and activity-dependent (repair) processes occurring during normal early development of the organism. This central idea will be addressed in an interdisciplinary Research Training Group embracing different model organisms, including man, using modern molecular biological, cell physiological and clinical methods, including imaging techniques.
In the section "Ontogenesis of the Nervous System", basic mechanisms of cell migration, synaptogenesis, axonal growth and axon-glia interactions will be addressed. In the section "Neurodegeneration and -regeneration", the molecular mechanisms of patho(physio)logical process induced by acute and progressive neuronal injury will be studied, including developmental processes (e.g. apoptosis). An additional aim of this section is the development of novel therapeutic strategies. Clinical aspects, ranging from the molecular biology of the GABAA receptor to functional imaging, will be studied in the section "Sensory function and dysfuntion". Interaction and cooperation between these three areas will lead to (a) the creation of new research approaches and (b) the establishment of novel interdisciplinary study programmes.
Graduate students of the medical and natural sciences will receive a broad theoretical and practical education in neuroscience through key lectures, a colloquium of invited speakers, a yearly meeting and various theoretical and laboratory courses. Close and continuous mentoring by the group leader and by experienced postdoctoral fellows will ensure a high standard of training.
In addition to the research-oriented education of graduate students, an aim of the Research Training Group is to promote research exchanges with foreign partner laboratories. The establishment of this Research Training Group will significantly strengthen the focus and activities in neuroscience at the University of Mainz.
In the section "Ontogenesis of the Nervous System", basic mechanisms of cell migration, synaptogenesis, axonal growth and axon-glia interactions will be addressed. In the section "Neurodegeneration and -regeneration", the molecular mechanisms of patho(physio)logical process induced by acute and progressive neuronal injury will be studied, including developmental processes (e.g. apoptosis). An additional aim of this section is the development of novel therapeutic strategies. Clinical aspects, ranging from the molecular biology of the GABAA receptor to functional imaging, will be studied in the section "Sensory function and dysfuntion". Interaction and cooperation between these three areas will lead to (a) the creation of new research approaches and (b) the establishment of novel interdisciplinary study programmes.
Graduate students of the medical and natural sciences will receive a broad theoretical and practical education in neuroscience through key lectures, a colloquium of invited speakers, a yearly meeting and various theoretical and laboratory courses. Close and continuous mentoring by the group leader and by experienced postdoctoral fellows will ensure a high standard of training.
In addition to the research-oriented education of graduate students, an aim of the Research Training Group is to promote research exchanges with foreign partner laboratories. The establishment of this Research Training Group will significantly strengthen the focus and activities in neuroscience at the University of Mainz.
DFG Programme
Research Training Groups
Applicant Institution
Johannes Gutenberg-Universität Mainz
Spokesperson
Professor Dr. Heiko J. Luhmann
Participating Researchers
Privatdozent Dr. Benjamin Altenhein; Professor Dr. Christian Behl; Dr. Christian Berger; Privatdozent Dr. Thomas Bela Berger; Professor Dr. Frank Birklein; Dr. Ingo Böhme; Dr. Albrecht Clement; Professor Dr. Ulrich Förstermann; Professor Dr. Werner Kilb; Professorin Dr. Eva-Maria Krämer-Albers; Professor Dr. Huige Li; Professor Dr. Beat Lutz; Professor Dr. Hartmut Lüddens; Dr. Krisztina Monory; Professor Dr. Holger Rabe; Professor Dr. Mathias Schreckenberger; Professor Dr. Peter Stoeter; Professor Dr. Gerhard M. Technau; Professorin Dr. Jacqueline Trotter-Kyewski; Professor Dr. Uwe Wolfrum
