Repurposing doxycycline in the treatment of cardiac AL amyloidosis

• Applicant: Professor Dr. Stefan Schönland
• Subject Area: Hematology, Oncology
• Term: from 2017 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 342064388

• Final Report Year: 2022

Final Report Abstract

The current clinical trial was started despite many difficulties related to the regulatory approvals from different European countries. The longer time for the complete approval and the impact of COVID-19 pandemic negatively influenced the recruitment rate and the trial conduct. As previously stated, the negative results from a clinical trial exploring the use of doxycycline in AL amyloidosis and the low recruitment rate, led to the anticipated closure of the study.