Modulation of Alzheimer-associated gamma-secretase by the lipid environment

• Applicant: Professor Dr. Harald Steiner
• Subject Area: Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 321765742

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Bexarotene binds to the amyloid precursor protein transmembrane domain, alters ist a-helical conformation, and inhibits y-secretase nonselectively in liposomes. ACS Chemical Neuroscience, Vol.9. 2018, Issue 7, pp. 1702-1713.
  Kamp. F., Scheidt, H.A., Winkler, E., Basset. G., Heinel, H., Hutchison, J.M., LaPointe, L.M., Sanders, C.R., Steiner, H. & Huster, D.
  (See online at https://doi.org/10.1021/acschemneuro.8b00068)
• Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol. Molecules, Vol. 24. 2019, Issue 13, 2353.
  Junker, J., Chong, I., Kamp, F., Steiner, H., Giera, M., Muller, C. & Bracher, F.
  (See online at https://doi.org/10.3390/molecules24132353)
• Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1862. 2020, Issue 5, 183200.
  Kong, Li, Dawkins, E., Campbell, F., Winkler, E., Derks, R., Giera, M., Kamp, F., Steiner, H. & Kros, A.
  (See online at https://doi.org/10.1016/j.bbamem.2020.183200)