Exposure treatment in anxiety disorders: proof of principle for an a priori response prediction approach (C09*)

• Subject Area: Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 44541416

The aim of C08 is to a priori predict treatment outcome in anxiety disorders following behavioral exposure based on neurobiological measures with high accuracy in a second, independent sample. We will build upon findings from previous mechanistic studies of the CRC and incorporate them into the development of a predictive pattern comprising fear-relevant (epi-) genotypes, neuropsychological, phenotype and neuroimaging markers. Multivariate pattern analyses embedded within a machine learning framework will be used to generate predictions on the individual patient level and to cross-validate markers in a second sample. We expect this project to bridge the translational gap between basic and clinical research and bring stratified medicine approaches into reach as one of the long-term goals of this CRC.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 58: Fear, Anxiety, Anxiety Disorders
• Applicant Institution: Universität Münster
• Co-Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Udo Dannlowski; Professorin Dr. Ulrike Lüken