Unraveling the relation between adult-born hippocampal neurons’ circuit activity and resilience (A02)

• Subject Area: Biological Psychiatry
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264810226

Hippocampal adult neurogenesis has been linked to resilient behavior, however the mechanistic basis is still unclear. It seems that not only higher rates of neurogenesis protect against chronic social defeat stress in rodents, but also the neuronal networking profile of adult born dentate gyrus granule cells. The main goal of the last funding was to elucidate individual correlates of presynaptic connectivity in adult born neurons in resilient and susceptible animals. Since we did not find evidence for our hypothesis, we now aim at identifying divergent neuronal network activity of adult born granule cells by using a novel AAV-tagging system including chemogenetic methods.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1193: Neurobiology of Resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Benedikt Berninger; Privatdozentin Dr. Julia Leschik