Organization of mitochondrial DNA-protein complexes and mitochondrial cytopathy of the kidney (C04)

• Subject Area: Biochemistry
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246781735

Kidneys are one of the major oxygen consuming organs in the human body. Oxygen is consumed at the mitochondrial respiratory chain. In this way, the energy from food drives the cellular metabolism. Since proteins involved in the respiratory chain are encoded on mitochondrial DNA, nephrotic syndromes develop in case mitochondrial DNA is lacking. In order to elucidate the pathogenesis of kidney diseases, the aim of this project is to find the cause for mitochondrial genome deficiencies and to analyze the organization of mitochondrial DNA.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1140: Kidney Disease - from Genes to Mechanisms (KIDGEM)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Nils Wiedemann