Project Details
Projekt
Protection of malaria by haemoglobin S and C: A quantitative understanding of the cytoadhesion behavior (03)
Subject Area
Parasitology and Biology of Tropical Infectious Disease Pathogens
Term
since 2014
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 240245660
The primary goal of this project is to unravel the mechanism by which the sickle cell trait protects carriers from severe malaria. We will correlate distinct modulations in cell mechanical properties and the effect of altered knob morphology and density on cell mechanics with the ability of parasitized erythrocytes to en-gage in disease-mediating cytoadhesive interactions and to pass splenic slits or to be mechanically cleared by them. The project combines expertise from molecular parasitology (Lanzer) and biophysics (Tanaka).
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Heads
Professor Dr. Michael Lanzer; Professor Dr. Motomu Tanaka
