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Identifizierung spezifischer tumoraffiner Peptide für HNO-Malignomen mittels Display-Techniken
Antragstellerinnen / Antragsteller
Professor Dr. Uwe Haberkorn; Professorin Dr. Christel Herold-Mende
Fachliche Zuordnung
Pharmazie
Nuklearmedizin, Strahlentherapie, Strahlenbiologie
Nuklearmedizin, Strahlentherapie, Strahlenbiologie
Förderung
Förderung von 2014 bis 2018
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 256151267
Erstellungsjahr
2018
Zusammenfassung der Projektergebnisse
In conclusion, we successfully identified a novel stable av06 integrin-specific peptide with high affinity for a variety of HNSCC tumors and further carcinomas. We observed a strong accumulation of the SFTIGv6 peptide in different tumors, but not in inflammatory lesions and tumor-free healthy tissues of patients. Therefore, SFITGv6 represents a promising tracer for imaging and possibly therapy of several carcinomas expressing the av06 integrin. However, the theranostic application of SFITGv6 to avb6 integrin-positive tumor lesions below the diaphragm (e.g. pancreatic and ovarian cancer) requires the modulation and improvement of the pharmacokinetic properties of the peptide.
Projektbezogene Publikationen (Auswahl)
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Identification of a Novel ITGavß6-Binding Peptide Using Protein Separation and Phage Display. Clin Cancer Res. 2017 Aug 1;23(15):4170-4180
Altmann A, Sauter M, Roesch S, Mier W, Warta R, Debus J, Dyckhoff G, Herold-Mende C, Haberkorn U
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Comparative study of the novel RGD Motif-containing avß6 Integrin Binding Peptides SFLAP3 and SFITGv6 for Diagnostic Application in HNSCC. J Nucl Med. 2018 Apr 19
Roesch S, Lindner T, Sauter M, Loktev A, Flechsig P, Müller M, Mier W, Warta R, Dyckhoff G, Herold-Mende C, Haberkorn U, Altmann A