Control of vascular guidance by apelin signalling (A11)

• Subject Area: Anatomy and Physiology
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

The major aims of this project are to decipher the mechanisms of Apelin signalling during angiogenesis. To achieve these goals we plan to use the zebrafish model for high resolution live imaging in combination with loss-of-function mutants for the Apelin receptors and ligands. By analysing the transcriptome and proteome of human and mouse endothelial cells deficient for the Apelin receptor, we also aim to identify downstream effectors of Apelin signalling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Christian Helker; Professor Dr. Didier Y. Stainier, Ph.D.