Analysis of adhesive properties of embryonic cells during zebrafish gastrulation
Zusammenfassung der Projektergebnisse
Tissue morphogenesis during embryonic development is brought about by mechanical forces, which are generated by the specific biophysical and motility properties of its constituent cells. It has also been suggested that embryonic tissues behave like immiscible liquids with a given surface tension and that differences in surface tension between tissues determine their spatial configuration during embryogenesis. To understand how single cell biophysical and motility properties regulate tissue surface tension and how tissue surface tension controls tissue organization in development, we are studying the specific function of germ layer progenitor cell adhesion, cell cortex tension and motility in determining germ layer organization during zebrafish gastrulation. We found that the combinatorial activity of progenitor cell adhesion, cortex tension and motility determines germ layer tissue surface tension and that differences in germ layer tissue surface tension influence germ layer organization during gastrulation.
Projektbezogene Publikationen (Auswahl)
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Quantitative differences in tissue surface tension influence zebrafish germ layer positioning. HFSP J. 2008 Feb;2(1):42-56
Schötz EM, Burdine RD, Jülicher F, Steinberg MS, Heisenberg CP, Foty RA
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Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol. 2008 Apr;10(4):429-36
Krieg M, Arboleda-Estudillo Y, Puech PH, Käfer J, Graner F, Müller DJ, Heisenberg CP
