The contact system in liver inflammation – interface of inflammation, coagulation and innate immunity (B08)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

The polyphosphate/factor XII-driven contact system provides a paradigm to elucidate proinflammatory and procoagulant mechanisms. We aim to analyse functions of the polyphosphate/factor XII-axis in inflammatory, immune, infectious, and malignant liver diseases. Our translational proposal comprises transgenic mice with deficiencies in the polyphosphate/factor XII-pathway and systems biology-based analyses of human liver diseases transcriptomes. The sum of our studies will improve our understanding on the contributions of the polyphosphate/factor XII-driven contact system in liver disease states and its role as potential drug target.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Thomas Renné