EXC 147: Kardiopulmonales System
Zusammenfassung der Projektergebnisse
Herz- und Lungenerkrankungen stellen weltweit die häufigsten Todesursachen mit hoher sozioökonomischer Belastung und immer noch unzureichenden Behandlungsmöglichkeiten dar. Der Exzellenz-Cluster Cardio-Pulmonales System (ECCPS), welcher die Universitäten in Frankfurt und Giessen und das Max-Planck Institut für Herz- und Lungenforschung in Bad Nauheim umfasst, vereinigt Grundlagenforschung mit klinischer Forschung auf folgenden Themengebieten: • Stamm/Progenitor-Zellen in kardio-pulmonaler Entwicklung, Organerhalt und Regeneration. • Vaskuläres und kardiales “Remodelling”, Entwicklung Remodelling-revertierender Therapien. • Angiogenese und Alveologenese in Physiologie, Regeneration und Reparatur. • Matrix-Homöostase und adaptive versus maladaptive mesenchymale Prozesse in der Fibrose. • Redox-abhängige Signaltransduktion und deren Beeinflussung in Hypoxie und Ischämie. • Integrität der vaskulären und alveolären Schranke bei Inflammation und Reparatur. • Schnittstelle zwischen dem endokrinen/metabolischen und dem vaskulären System. • Identifikation von Biomarkern und molekularen Signaturen für personalisierte Medizin. ECCPS-WissenschaftlerInnen haben zahlreiche grundlegende Beiträge zur Entwicklung der kardiopulmonalen Forschung geleistet, belegt durch hochrangige Publikationen und die Koordination großer nationaler und internationaler Forschungsverbünde. Insbesondere hervorzuheben ist die Übertragung innovativer Konzepte in die klinische Anwendung, dokumentiert durch erfolgreiche sowie laufende Phase II/III Studien und zahlreiche Patente. In ECCPS II wurden neue Forschungsansätze in alle genannten Themengebiete eingebracht (z.B. Epigenetik, Metabolomik, molekulare in-vivo Bildgebung) und eine neue Internationale Forschungsplattform mit dem Imperial College, London, und globalen Partnern zur Erforschung und Behandlung von pulmonal-vaskulären Erkrankungen mit hoher gesundheitlicher Bedeutung in Ländern der Dritten Welt gegründet. Zudem haben wir eine langfristig angelegte Technologieplattform eingerichtet, welche den Zugang aller ECCPS Fakultätsmitglieder zu neuesten Technologien sicherstellt (z.B. Bioinformatik, “omic“-Techniken, hochauflösende EXC147 Final Report Bildgebung). Zur Förderung des wissenschaftlichen Nachwuchses haben wir die ECCPS Akademie eingerichtet, um die erfolgreich laufenden Graduierten-Kollegs durch Postdoktoranden- und Programme der Karriereentwicklung zu komplettieren. Diese Maßnahmen haben den ECCPS in seiner Mission, die molekulare Pathogenese von vaskulären und parenchymatösen Herz- und Lungenerkrankungen zu entschlüsseln und neue für die personalisierte Medizin geeignete Therapiekonzepte zu entwickeln, wesentlich gestärkt.
Link zum Abschlussbericht
https://dx.doi.org/10.2314/KXP:1697279635
Projektbezogene Publikationen (Auswahl)
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Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation. Nat Med 12:235-39, 2006
Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG
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Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355:1210-21, 2006
Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Holschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Suselbeck T, Assmus B, Tonn T, Dimmeler S, Zeiher AM
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Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 355:1222-32, 2006
Assmus B, Honold J, Schachinger V, Britten MB, Fischer-Rasokat U, Lehmann R, Teupe C, Pistorius K, Martin H, Abolmaali ND, Tonn T, Dimmeler S, Zeiher AM
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Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci USA 104:6388-93, 2007
Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, Ruppert C, Markart P, Song Y, Tzima E, Kennerknecht E, Niepmann M, von Bruehl ML, Sedding D, Massberg S, Günther A, Engelmann B, Preissner KT
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SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21:2644-58, 2007
Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S
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Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflame cell recruitment. Science 322:1101-4, 2008
Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T
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Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT–mediated clustering of CCR2. Cell Stem Cell 2:566-575, 2008
Belema-Bedada F, Uchida S, Martire A, Kostin S, Braun T
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G12-G13-LARG-mediated signaling in vascular smooth muscle is required for saltinduced hypertension. Nat Med 14:64-68, 2008
Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Orsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind JS, Offermanns S
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Lung epithelial apoptosis in influenza virus pneumonia: The role of macrophage expressed TNF- related apoptosis-inducing ligand. J Exp Med 205:3065-77, 2008
Herold S, Steinmueller M, von Wulffen W, Cakarova L, Pinto R, Pleschka S, Mack M, Kuziel WA, Corazza N, Brunner T, Seeger W, Lohmeyer J
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Acquisition of the contractile phenotype of arterial smooth muscle cells depends on the miR- 143/145 gene cluster. J Clin Invest 119:2634-47, 2009
Boettger T, Beetz N, Kostin S, Schneider J, Krüger M, Hein L, Braun T
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An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol 11:85-91, 2009
Calzado MA, de la Vega L, Möller A, Bowtell DL, Schmitz ML
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Anaphylactic shock depends on endothelial Gq/G11. J Exp Med 206:411-20, 2009
Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S.
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Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. J Exp Med 206:2889-96, 2009
Loot AE, Schreiber JG, Fisslthaler B, Fleming I
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Epidermal growth factor-like 7 (EGFL7) modulates Notch signaling and effects neural stem cell renewal. Nat Cell Biol 11:873-80, 2009
Schmidt MHH, Bicker F, Nikolic I, Meister J, Babuke T, Piciric S, Muller-Esterl W, Plate KH, Dikic I
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MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324:1710-13, 2009
Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher A, Dimmeler S
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Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. Circulation 119:1747-57, 2009
Grünig E, Weissmann S, Ehlken N, Fijalkowska A, Fischer C, Fourme T, Galié N, Ghofrani HA, Harrison RE, Huez S, Humbert M, Janssen B, Kober J, Koehler R, Machado RD, Mereles D, Naeije R, Olschewski H, Provencher S, Reichenberger F, Retailleau K, Rocchi G, Simonneau G, Torbicki A, Trembath R, Seeger W
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WNT1-inducible signalling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 119:772-87, 2009
Königshoff M, Kramer M, Balsara N, Wilhelm J, Amarie OV, Jahn A, Rose F, Fink L, Seeger W, Schaefer L, Günther A, Eickelberg O
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An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab 11:311-19, 2010
Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S
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EphrinB2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 65:487-91, 2010
Sawamiphak S, Seidel S, Essmann CL, Wilkinson GA, Pitulescu M, Acker T, Acker- Palmer A
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Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome associated interstitial pneumonia. Am J Respir Crit Care Med 182:207-219, 2010
Mahavadi P, Korfei M, Henneke I, Liebisch G, Schmitz G, Gochuico BR, Markart P, Seeger W, Ruppert C, Günther A
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The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120:4251-72, 2010
Moreth K, Brodbeck R, Babelova A, Gretz N, Spieker T, Zeng-Brouwers J, Pfeilschifter J, Young M, Schaefer RM, Schaefer L
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cAMP phosphordiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases. Circulation 123:1194-204, 2011
Pullamsetti SS, Savai R, Schaefer MB, Wilhelm J, Ghofrani HA, Weissmann N, Schudt C, Fleming I, Mayer K, Leiper J, Seeger W, Grimminger F, Schermuly RT
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Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell 147:293-305, 2011
Seimetz M, Parajuli N, Pichl A, Veit F, Kwapiszewska G, Weisel FC, Milger K, Egemnazarov B, Turowska A, Fuchs B, Nikam S, Roth M, Sydykov A, Medebach T, Klepetko W, Jaksch P, Dumitrascu R, Garn H, Voswinckel R, Kostin S, Seeger W, Schermuly RT, Grimminger F, Ghofrani HA, Weissmann N
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Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1. Proc Natl Acad Sci USA 108:3276-81, 2011
Boeckel JN, Guarani V, Koyanagi M, Röxe T, Lengeling A, Schermuly TR, Gellet P, Braun T, Zeiher A, Dimmeler S
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Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest 121:2470-9, 2011
Clauss M, Voswinckel R, Rajashekhar G, Sigua NL, Fehrenbach H, Rush NI, Schweitzer KS, Yildirim AÖ, Kamocki K, Fisher AJ, Gu Y, Safadi B, Nikam S, Hubbard WC, Tuder RM, Twigg HL 3rd, Presson RG, Sethi S, Petrache I
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MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res 109:1115-1119, 2011
Boon RA, Seeger T, Heydt S, Fischer A, Hergenreider E, Horrevoets AJ, Vinciguerra M, Rosenthal N, Sciacca S, Pilato M, van Heijningen P, Essers J, Brandes RP, Zeiher AM, Dimmeler S
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Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell 9:420-32, 2011
Kubin T, Poling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lorchner H, Schimanski S, Szibor M, Warnecke H and Braun T
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Transcoronary concentration gradients of circulating microRNAs. Circulation 124:1936-44, 2011
De Rosa S, Fichtlscherer S, Lehmann R, Assmus B, Dimmeler S, Zeiher AM
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A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell 46:472-483, 2012
De la Vega L, Grishina I, Moreno R, Krüger M, Braun T, Schmitz ML
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Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 473: 234-8, 2011
Guarani V, Deflorian G, Franco CA, Kruger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M
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Acute myocardial infarction activates progenitor cells and increases Wnt signaling in the bone marrow. Eur Heart J 33:1911-1919, 2012
Assmus B, Iwasaki M, Schächinger V, Roexe T, Koyanagi M, Iekushi K, Xu Q, Tonn T, Seifried E, Liebner S, Kranert WT, Grünwald F, Dimmeler S, Zeiher AM
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Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest 122:3652-3664, 2012
Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Janssen H, Seeger W, Lohmeyer J, Herold S
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Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nature Cell Biol 14:249-256, 2012
Hergenreider E, Heydt S, Treguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S
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Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 186:897-908, 2012
Savai R, Pullamsetti SS, Kolbe J, Bieniek E, Voswinckel R, Fink L, Scheed A, Ritter C, Dahal BK, Vater A, Klussmann S, Ghofrani HA, Weissmann N, Klepetko W, Banat GA, Seeger W, Grimminger F, Schermuly RT
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Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res 110:1217-1225, 2012
Schröder K, Zhang M, Benkhoff S, Mieth A, Pliquett R, Kosowski J, Kruse C, Luedike P, Michaelis UR, Weissmann N, Dimmeler S, Shah AM, Brandes RP
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Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med 209:2277-2290, 2012
Althoff TF, Juarez JA, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N, Offermanns S
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Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction. Circulation 125:1765-73, 2012
Iekushi K, Seeger F, Assmus B, Zeiher AM, Dimmeler S
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Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med 188: 1451-1459, 2013
Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ahlbrecht K, Fecher-Trost C, Flockerzi V, Ghofrani HA, Grimminger F, Seeger W, Gudermann T, Dietrich A, Weissmann N
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Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELL- WAVE randomized clinical trial. J Am Med Assoc 309:1622-1631, 2013
Assmus B, Walter DH, Seeger FH, Leistner DM, Steiner J, Ziegler I, Lutz A, Khaled W, Klotsche J, Tonn T, Dimmeler S, Zeiher AM
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G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell 25:427-434, 2013
Sivaraj KK, Takefuji M, Schmidt I, Adams RH, Offermanns S, Wettschureck N
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Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation 127:1128-1138, 2013
Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez MA, Grimminger F, Grünig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T, Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA
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Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model. Circulation 128:1066-1075, 2013
Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, Dimmeler S
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Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia. PLoS Pathog 9:e1003188, 2013
Hogner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlohner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S
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MicroRNA-223 antagonizes angiogenesis by targeting β1 integrin and preventing growth factor signaling in endothelial cells. Circ Res 113:1320-1330, 2013
Shi L, Fisslthaler B, Zippel N, Frömel T, Hu J, Elgheznawy A, Heide H, Popp R, Fleming I
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MicroRNA-34a regulates cardiac ageing and function. Nature 495:107-110, 2013
Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kalua D, Treguer K, Carmona G, Bonauer A, Horrevoets AJ, Didler N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Dimmeler S
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Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. Cell Stem Cell 13:590-601, 2013
Günther S, Kim, J, Kostin S, Leppe, C Fan CM, Braun T
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NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest. 123:4731-4738, 2013
Goettsch C, Babelova A, Trummer O, Erben RG, Rauner M, Rammelt S, Weissmann N, Weinberger V, Benkhoff S, Kampschulte M, Obermayer-Pietsch B, Hofbauer LC, Brandes RP, Schröder K
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Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24:130-137, 2013
Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S
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RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. J Exp Med 210: 665-673, 2013
Takefuji M Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N
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Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med 369:319-329, 2013
Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C, CHEST-1 Study Group
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Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med 369:330-340, 2013
Ghofrani HA, Galie N, Grimminger F, Grunig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ, PATENT-1 Study Group
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The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res 112:924-934, 2013
Michaelis UR, Chavakis E, Kruse C, Jungblut B, Kaluza D, Wandzioch K, Manavski Y, Heide H, Santoni MJ, Potente M, Eble JA, Borg JP, Brandes RP
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glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med 211:281-295, 2014
Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams RH, Hammes HP, Fleming I. Müller
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Inhaled granulocyte/macrophage colony-stimulating factor as treatment of pneumonia-associated acute respiratory distress syndrome. Am J Respir Crit Care Med 189:609-611, 2014
Herold S, Hoegner K, Vadasz I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath HD, Seeger W, Lohmeyer J
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Long-term clinical outcome after intracoronary application of bone marrow-derived mononuclear cells for acute myocardial infarction: Migratory capacity of administered cells determines event-free survival. Eur Heart J 35:1275-1283, 2014
Assmus B, Leistner DM, Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Sedding D, Yu J, Corti R, Mathey DG, Barth C, Mayer-Wehrstein C, Burck I, Sueselbeck T, Dill T, Hamm CW, Tonn T, Dimmeler S, Zeiher AM
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Prehospital ticagrelor in ST-segment elevation myocardial infarction. N Engl J Med. 371:1016-27, 2014
Montalescot G, van 't Hof AW, Lapostolle F, Silvain J, Lassen JF, Bolognese L, Cantor WJ, Cequier A, Chettibi M, Goodman SG, Hammett CJ, Huber K, Janzon M, Merkely B, Storey RF, Zeymer U, Stibbe O, Ecollan P, Heutz WM, Swahn E, Collet JP, Willems FF, Baradat C, Licour M, Tsatsaris A, Vicaut E, Hamm CW; ATLANTIC Investigators
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Proproliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension. Nature Med 20:1289-1300, 2014
Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti S
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RBM24 is a major regulator of muscle-specific alternative splicing. Dev Cell 31:87-99, 2014
Yang J, Hung L-H, Licht T, Kostin S, Looso M, Khrameeva E, Bindereif A, Schneider A, Braun T
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Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema. Am J Respir Crit Care Med 189: 1359-1373, 2014
Weissmann N, Lobo B, Pichl A, Parajuli N, Seimetz M, Puig-Pey R, Ferrer E, Peinado VI, Domínguez-Fandos D, Fysikopoulos A, Stasch JP, Ghofrani HA, Coll-Bonfill N, Frey R, Schermuly RT, García-Lucio J, Blanco I, Bednorz M, Tura-Ceide O, Tadele E, Brandes RP, Grimminger J, Klepetko W, Jaksch P, Rodriguez-Roisin R, Seeger W, Grimminger F, Barberà JA
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The long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res 114:1389-1397, 2014
Michalik KM, You X, Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, Boon RA, Dimmeler S
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Vitamin D promotes vascular regeneration. Circulation 130:976-986, 2014
Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP
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Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes. Circ Res 117:157-165, 2015
Elgheznawy A, Shi L, Hu J, Wittig I, Laban H, Pircher J, Mann A, Provost P, Randriamboavonjy V, Fleming I
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Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature 524:230-233, 2015
Rossi A, Kontarakis Z, Gerri C, Nolte H, Holper S, Kruger M, Stainier DY
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Intraindividual response to treatment with pirfenidone in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 191:110-3, 2015
Loeh B, Drakopanagiotakis F, Bandelli GP, von der Beck D, Tello S, Cordani E, Rizza E, Barrocu L, Markart P, Seeger W, Guenther A, Albera C
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Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med 21: 173-177, 2015
Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S
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Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer. Am J Respir Crit Care Med 191:437-447, 2015
Schmall A, Al-Tamari HM, Herold S, Kampschulte M, Weigert A, Wietelmann A, Vipotnik N, Grimminger F, Seeger W, Pullamsetti SS, Savai R
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Myocardial healing requires Reg3beta-dependent accumulation of macrophages in the ischemic heart. Nature Med 21:353-362, 2015
Lorchner H, Poling J, Gajawada P, Hou Y, Polyakova V, Kostin S, Adrian-Segarra JM, Boettger T, Wietelmann A, Warnecke H, Richter M, Kubin T, Braun T
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Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 522:354-358, 2015
Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Kalona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I
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The intersection of the extrinsic hedgehog and WNT/Wingless signals with the intrinsic Hox code underpins branching pattern and tube shape diversity in the drosophila airways. PLoS Genet 11:e1004929, 2015
Matsuda R, Hosono C, Saigo K, Samakovlis C
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The Isl1/Ldb1 complex orchestrates genome-wide chromatin organization to instruct differentiation of multipotent cardiac progenitors. Cell Stem Cell 17:287-299, 2015
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld P, Dobreva G
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The NADPH oxidase Nox4 has antiatherosclerotic functions. Eur Heart J 36:3447-3456, 2015
Schürmann C, Rezende F, Kruse C, Yasar Y, Löwe O, Fork C, van de Sluis B, Bremer R, Weissmann N, Shah AM, Jo H, Brandes RP, Schröder K
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Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Nat Cell Biol 17:1569-1576, 2015
Hosono C, Matsuda R, Adryan B, Samakovlis C
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Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated posttranscriptional regulation. Nature Med 22:1140-1150, 2016
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jae N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S
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Cloche is a bHLH-PAS transcription factor that drives haematovascular specification. Nature 535:294-298, 2016
Reischauer S, Stone OA, Villasenor A, Chi N, Jin SW, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung WS, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DY
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Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest 126:4527-4536, 2016
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