Decoding kinase-mediated signaling networks promoting lipolysis in health and disease

• Applicant: Privatdozent Grzegorz Sumara, Ph.D.
• Subject Area: Endocrinology, Diabetology, Metabolism ; Biochemistry ; Cell Biology
• Term: from 2014 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 245619385

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling. Sci Signal. 2019 Aug 6;12(593):eaav9150
  Mayer AE, Löffler MC, Loza Valdés AE, Schmitz W, El-Merahbi R, Viera JT, Erk M, Zhang T, Braun U, Heikenwalder M, Leitges M, Schulze A, Sumara G
  (See online at https://doi.org/10.1126/scisignal.aav9150)
• The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. Genes Dev. 2020 Apr 1;34(7-8):495-510
  El-Merahbi R, Viera JT, Valdes AL, Kolczynska K, Reuter S, Löffler MC, Erk M, Ade CP, Karwen T, Mayer AE, Eilers M, Sumara G
  (See online at https://doi.org/10.1101/gad.333617.119)