Sphingolipid- and Matrix –mediated Signalling pathways in chronic inflamation and fibrosis of the kidney (B02)

• Subject Area: Pharmacology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 204083920

This project aims at investigating the therapeutic potential of specific inhibitors of S1PR5, the Spns2 transporter and of a novel S1PR1 G protein-biased agonist for an antifibrotic effect in kidney injury models. Mechanistically, the decreased degradation of antifibrotic Smad7 due to sphingosin-mediated reduction of ubiquitin ligases will be elucidated. Further experiments will particularly address the impact of specific chain-lengths of S1P and the crosstalk of S1P and the proteoglycan biglycan in renal inflammation, resolution and fibrosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1039: Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Josef M. Pfeilschifter; Professorin Dr. Liliana Schaefer