Chemoenzymatische Totalsynthese der Ambruticine und Jerangolide

• Antragsteller: Professor Dr. Frank Hahn
• Fachliche Zuordnung: Biologische und Biomimetische Chemie
• Förderung: Förderung von 2012 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 227750349

This project aims to make late-stage biosynthetic enzymes (tailoring enzymes) from polyketide biosynthesis applicable as biocatalytictools for chemical natural product synthesis. According to their natural role, they will be used to substitute lateand crucialstepsin the endgameof total syntheses. Thereby, thetarget structures for the synthetic part are simpler and derivatives become easier accessible. The usefulness of the chosen approach will be demonstrated onthe ambruticins and the jerangolids.Chemoenzymatic total synthesesthat merge chemical synthesis with biosynthesis will be developedand be used to accessnovel derivatives.

• DFG-Verfahren: Emmy Noether-Nachwuchsgruppen