Neural, hormonal and behavioral mechanisms of long-term weight maintenance

• Antragsteller: Professor Dr. John-Dylan Haynes
• Fachliche Zuordnung: Kinder- und Jugendmedizin ; Endokrinologie, Diabetologie, Metabolismus
• Förderung: Förderung von 2012 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 101434729

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

In this project, we have evaluated the link between brain activity or behavioural parameters acquired with two functional paradigms (food cue-reactivity and delay discounting) and body mass changes in (initially) obese patients assessed across a time period of 39 month. By using the functional paradigms, which are also applied in research on substance-related disorders, we have found that BMI changes are related to activity in neural networks that largely overlap in terms of spatial location and function with networks involved in substance-related disorders. This overlap suggests, that shared biological systems underlie the maintenance of the diseases. These findings can be utilized in therapeutic approaches applied to treat obesity.

Projektbezogene Publikationen (Auswahl)

• Role of neural impulse control mechanisms for dietary success in obesity. NeuroImage. 2013; 83: 669 - 678
  Weygandt M, Mai K, Dommes E, Leupelt V, Hackmack K, Kahnt T, Rothemund Y, Spranger J, Haynes JD
  (Siehe online unter https://doi.org/10.1016/j.neuroimage.2013.07.028)
• DLPFC impulse control counteracts a yo-yo effect in post-diet weight maintenance. NeuroImage. 2015; 109: 318 – 327
  Weygandt M, Mai K, Dommes E, Hackmack K, Leupelt V, Spranger J, Haynes JD
  (Siehe online unter https://doi.org/10.1016/j.neuroimage.2014.12.073)