Molecular mechanism of the heat shock transcription factor Hsf1 (09)

• Subject Area: Biochemistry
• Term: from 2012 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542

TP09 investigates how the response of cells to proteotoxic stress is regulated at a molecular level. One focus of the project is the analysis of the structure of monomeric and trimeric human heat shock transcription factor Hsf1 and the development of an Hsf1 based bioluminescence resonance energy transfer sensor that could be used to screen for Hsf1 activating and Hsf1 inhibiting small molecules as therapeutics for cancer and neurodegenerative diseases. The second focus is the molecular mechanism of the modulation of Hsf1 activation and attenuation by posttranslational modifications and interacting proteins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1036: Cellular Surveillance and Damage Response
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Matthias Peter Mayer