Transcriptional and epigenetic control by Sirtuins in response to stress (01)

• Subject Area: Cell Biology
• Term: from 2012 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542

The project of Renate Voit and Ingrid Grummt (TP01) seeks to understand the transcription-associated mechanisms that safeguard cellular homeostasis. They will use genome-wide approaches to identify novel targets and pathways that are targeted by the NAD+-dependent protein deacetylase SIRT7 and compare the functional impact of stress on SIRT7-associated proteins. In addition, they will explore the molecular mechanisms that prevent unscheduled formation of R-loops, which represent a potential threat to genome stability. The fact that SIRT7 knockout leads to accumulation of R-loops and causes genomic instability will open up new avenues for understanding the role of acetylation in cellular surveillance and damage response pathways.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1036: Cellular Surveillance and Damage Response
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Deutsches Krebsforschungszentrum (DKFZ)
• Project Heads: Professorin Dr. Ingrid Grummt; Dr. Renate Voit, until 7/2017