Role of IL-6 in shaping local immune milieus in the CNS (A07)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

IL-6 is increasingly identified as therapeutic target for a variety of inflammatory human diseases including Multiple Sclerosis. Due to the complexity of IL-6 directed interventions and differential responses of the distinct IL-6 signaling modalities to therapies, we now set out to investigate responses to IL-6 in the CNS in detail. We will asses the most relevant sources of IL-6 in the CNS, address the role of IL-6 signaling into conventional T cells and Foxp3+ Treg cells in the CNS during autoimmune inflammation, and finally study the impact of IL-6 on the formation of unique Treg cell niches during recovery from EAE.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Thomas Korn; Professor Dr. Ari Waisman