Interplay between pro-inflammatory cytokines and chromatin-remodeling enzymes in the regulation of central nervous system demyelination and repair (A03)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

Our work suggests that modulating the activity of HDAC1/2 could have multiple beneficial effects in the context of MS by decreasing IL-17 and TNF-induced demyelination and enhancing remyelination of lesions. Here we propose to use genetic mouse models as well as human induced pluripotent stem cells (iPSC)-derived neural cells to study the role of HDAC1/2 and IL-17/TNF signaling and their interplay on myelination and remyelination of the CNS in the context of inflammation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professorin Dr. Claire Jacob, since 1/2021; Professor Dr. Ari Waisman; Professorin Dr. Nina Wettschureck, until 12/2020