Gentransfer in mesenchymale Stammzellen zur Knorpelreparation - Modulation der hypertrophen Chondrogenese und in vivo Applikation

• Antragsteller: Professor Dr. Andre Steinert
• Fachliche Zuordnung: Orthopädie, Unfallchirurgie, rekonstruktive Chirurgie
• Förderung: Förderung von 2006 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 21827687

• Erstellungsjahr: 2012

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Research & Therapy, Vol. 9. 2007, Issue 3: 213.
  Steinert A.F., Ghivizzani S.C., Rethwilm A., Tuan R.S., Evans C.H., Nöth U.
  
• Concepts in gene therapy for cartilage repair. Injury 2008; 39S1: S97-113. [1F:1.509] (Anlage 2) Injury, Vol. 39. 2008, Issue 1, Supplement, pp. 97–113.
  Steinert A.F., Nöth U., Tuan R.S.
  
• Technology Insight: adult mesenchymal stem cells for osteoarthritis therapy. Nature Clinical Practice Rheumatology, Vol. 4. 2008, Issue 7, pp. 371-380.
  Nöth U., Steinert A.F., Tuan R.S.
  
• Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Engineering Part A, Vol. 15. 2009, Issue 5, pp. 1127-1139.
  Steinert A.F., Palmer G.D., Gouze E., Gouze J.N., Pilapil C., Nöth U., Evans C.H., Ghivizzani S.C.
  
• Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Research & Therapy, Vol. 11.2009: R148.
  Steinert A.F., Proffen B., Kunz M., Hendrich C., Ghivizzani S., Nöth U., Eulert J., Evans C.
  
• Cell Delivery Therapeutics for Musculoskeletal Regeneration. Advanced Drug Delivery Reviews, Vol. 62. 2010, Issues 7–8, pp. 765–783.
  Nöth U., Rackwitz L., Steinert A., Tuan R.
  
• Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives. Stem Cells Translational Medicine, Vol. 1. 2012, Number 3, pp. 237-247.
  Steinert A.F., Rackwitz L., Gilbert F., Nöth U., Tuan R.
  
• Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells. Arthritis Research & Therapy, Vol. 14. 2012: R168.
  Steinert A.F., Weissenberger M., Kunz M., Gilbert F., Ghivizzani S.C., Göbel S., Jakob F., Nöth U., Rudert M.