The Function and role of Basal Ganglia pathways: From single to multiple loops

• Applicants: Professor Dr.-Ing. Fred Henrik Hamker; Professorin Dr. Andrea Kühn
• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: from 2012 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 215316884

• Final Report Year: 2018

Final Report Abstract

The project “The function and role of Basal Ganglia Pathways: From single to multiple loops” has been funded as part of the German-Japanese Collaboration in Computational Neuroscience initiative. It combined neuro-computational modelling of Basal Ganglia pathways with basic neuroscience research and patient studies. We developed a novel interpretation of the pathway between the subthalamic nucleus (STN) and the external globus pallidus (GPe). Further, we increased our understanding of changes in the Basal Ganglia pathways in Huntington’s and Parkinsons’s disease.

Publications

• (2013) Computational models of basal-ganglia pathway functions: Focus on functional neuroanatomy. Frontiers in Systems Neuroscience, 7:122
  Schroll H., Hamker, F.H.
  (See online at https://doi.org/10.3389/fnsys.2013.00122)
• (2015) A spiking neural network based on the basal ganglia functional anatomy. Neural Networks, 67:1-13
  Baladron, J., Hamker, F.H.
  (See online at https://doi.org/10.1016/j.neunet.2015.03.002)
• (2015) Combined lesions of direct and indirect basal ganglia pathways but not changes in dopamine levels explain learning deficits in patients with Huntington's disease. European Journal of Neuroscience, 41:1227-1244
  Schroll, H., Beste, C., Hamker, F.H.
  (See online at https://doi.org/10.1111/ejn.12868)
• (2016) Basal ganglia dysfunctions in movement disorders: What can be learned from computational simulations. Movement Disorders, 31:1591-1601
  Schroll, H., Hamker, F.H.
  (See online at https://doi.org/10.1002/mds.26719)
• (2016) Fast and Slow Learning in a Neuro- Computational Model of Category Acquisition. In: A.E.P. Villa et al. (Eds.): ICANN 2016, Part I, LNCS 9886. 248-255
  Villagrasa, F., Baladron, J., Hamker, F.H.
  (See online at https://doi.org/10.1007/978-3-319-44778-0_29)
• (2017) Effects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease. Neuropsychiatr Dis Treat. 2017 Jun 19;13:1603-1611
  Merkl A, Röck E, Schmitz-Hübsch T, Schneider GH, Kühn AA
  (See online at https://doi.org/10.2147/NDT.S126397)
• (2017) The subthalamic nucleus - external globus pallidus loop biases exploratory decisions towards known alternatives: A neurocomputational study. European Journal of Neuroscience
  Baladron, J., Nambu, A., Hamker, F.H.
  (See online at https://doi.org/10.1111/ejn.13666)
• (2017). Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in nondemented Parkinson’s patients. Journal of Neural Transmission, 124, 1073-1081
  Kübler, D., Schroll, H., Buchert, R., & Kühn, A. A.
  (See online at https://doi.org/10.1007/s00702-017-1747-2)
• (2017). Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson’s Disease. Social Cognitive and Affective Neuroscience, 12, 1594-1604
  Irmen, F., Huebl, J., Schroll, H., Brücke, C., Schneider, G.-H., Hamker, F. & Kühn, A. A.
  (See online at https://doi.org/10.1093/scan/nsx090)