The Function and role of Basal Ganglia pathways: From single to multiple loops

• Antragstellerinnen / Antragsteller: Professor Dr.-Ing. Fred Henrik Hamker; Professorin Dr. Andrea Kühn
• Fachliche Zuordnung: Kognitive, systemische und Verhaltensneurobiologie
• Förderung: Förderung von 2012 bis 2017
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 215316884

• Erstellungsjahr: 2018

Zusammenfassung der Projektergebnisse

The project “The function and role of Basal Ganglia Pathways: From single to multiple loops” has been funded as part of the German-Japanese Collaboration in Computational Neuroscience initiative. It combined neuro-computational modelling of Basal Ganglia pathways with basic neuroscience research and patient studies. We developed a novel interpretation of the pathway between the subthalamic nucleus (STN) and the external globus pallidus (GPe). Further, we increased our understanding of changes in the Basal Ganglia pathways in Huntington’s and Parkinsons’s disease.

Projektbezogene Publikationen (Auswahl)

• (2013) Computational models of basal-ganglia pathway functions: Focus on functional neuroanatomy. Frontiers in Systems Neuroscience, 7:122
  Schroll H., Hamker, F.H.
  (Siehe online unter https://doi.org/10.3389/fnsys.2013.00122)
• (2015) A spiking neural network based on the basal ganglia functional anatomy. Neural Networks, 67:1-13
  Baladron, J., Hamker, F.H.
  (Siehe online unter https://doi.org/10.1016/j.neunet.2015.03.002)
• (2015) Combined lesions of direct and indirect basal ganglia pathways but not changes in dopamine levels explain learning deficits in patients with Huntington's disease. European Journal of Neuroscience, 41:1227-1244
  Schroll, H., Beste, C., Hamker, F.H.
  (Siehe online unter https://doi.org/10.1111/ejn.12868)
• (2016) Basal ganglia dysfunctions in movement disorders: What can be learned from computational simulations. Movement Disorders, 31:1591-1601
  Schroll, H., Hamker, F.H.
  (Siehe online unter https://doi.org/10.1002/mds.26719)
• (2016) Fast and Slow Learning in a Neuro- Computational Model of Category Acquisition. In: A.E.P. Villa et al. (Eds.): ICANN 2016, Part I, LNCS 9886. 248-255
  Villagrasa, F., Baladron, J., Hamker, F.H.
  (Siehe online unter https://doi.org/10.1007/978-3-319-44778-0_29)
• (2017) Effects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease. Neuropsychiatr Dis Treat. 2017 Jun 19;13:1603-1611
  Merkl A, Röck E, Schmitz-Hübsch T, Schneider GH, Kühn AA
  (Siehe online unter https://doi.org/10.2147/NDT.S126397)
• (2017) The subthalamic nucleus - external globus pallidus loop biases exploratory decisions towards known alternatives: A neurocomputational study. European Journal of Neuroscience
  Baladron, J., Nambu, A., Hamker, F.H.
  (Siehe online unter https://doi.org/10.1111/ejn.13666)
• (2017). Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in nondemented Parkinson’s patients. Journal of Neural Transmission, 124, 1073-1081
  Kübler, D., Schroll, H., Buchert, R., & Kühn, A. A.
  (Siehe online unter https://doi.org/10.1007/s00702-017-1747-2)
• (2017). Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson’s Disease. Social Cognitive and Affective Neuroscience, 12, 1594-1604
  Irmen, F., Huebl, J., Schroll, H., Brücke, C., Schneider, G.-H., Hamker, F. & Kühn, A. A.
  (Siehe online unter https://doi.org/10.1093/scan/nsx090)