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Projekt Druckansicht

Identifizierung genetischer und epigenetischer Biomarker für die Thrombozytenfunktion und thrombozytenvermittelte inflammatorische Prozesse in einer etablierten prospektiven kardiologischen Patientenkohorte

Fachliche Zuordnung Kardiologie, Angiologie
Förderung Förderung von 2011 bis 2018
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 190538538
 

Zusammenfassung der Projektergebnisse

Epigenetic changes, such as DNA-methylation und miRNAs play an important role in various cardiovascular diseases like coronary artery disease and chronic heart failure. In addition to circulating miRNAs in the blood, endogenous metabolite levels were shown to be important biomarkers for the prognosis/prediction of cardiovascular diseases. The importance of these metabolites and circulating miRNAs for the function of platelets and platelet-induced processes such as inflammation, apoptosis and angiogenesis has not been examined extensively up to date. Therefore diagnostic, prognostic and therapeutic importance of epigenetic factors (e.g. circulating miRNAs) and endogenous metabolite levels should be examined additionally to previously investigated genetic factors of selected candidate genes in past funding periods. In order to be able to validly examine the clinical relevance of potential molecular biomarkers, an analysis of a prospectively identified cardiologic cohort is necessary, so additional influencing factors (age, diabetes mellitus, concomitant medication and dietary habits) can be evaluated. The prospective patient cohort with associated biobank and exact phenotypic characterization under standardized conditions established during the first and second funding period allowed for systematic analyses of epigenetic markers, such as e.g. circulating miRNAs and metabolite levels in vivo and for verification of their relevance for platelet function as well as platelet-induced inflammatory and regenerative processes. Another objective was to evaluate particular targets form other projects in connection with the newly identified biomarkers, to validate the basic research findings of those projects in the established patient cohort at an early stage.

Projektbezogene Publikationen (Auswahl)

 
 

Zusatzinformationen

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