NMR Investigations of the Self Organization and Dynamics of Amyloid Protein Fibrils (A06)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics ; Experimental and Theoretical Physics of Polymers
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 189853844

The goal of the project is to understand the fundamental basis of protein fibril formation. We study the different stages of the self-organization process and the structure and dynamics of the protein by NMR methods. To this end, we systematically alter well-known molecular contacts of amyloid β (Aβ40) peptides by introducing specific physical fields into these positions or modifying larger segments of the amyloid structure. These modifications act as internal constraints on the structure forming process.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 102: Polymers under Multiple Constraints: Restricted and Controlled Molecular Order and Mobility
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Jochen Balbach, until 6/2019; Professor Dr. Daniel Huster